What are the Challenges in Developing CSP-based Vaccines?
Despite the promise of CSP as a vaccine target, several challenges exist: - Genetic variability: The CSP gene exhibits considerable genetic diversity among different Plasmodium strains, which can affect the efficacy of the vaccine. - Immune evasion: The parasite has evolved mechanisms to evade the host's immune system, complicating vaccine development. - Durability of protection: The longevity of the immune response elicited by CSP-based vaccines remains a concern, necessitating booster doses to maintain protection.
