The Centers for Disease Control and Prevention (CDC) recommends that both boys and girls receive the HPV vaccine at ages 11 or 12, although it can be administered as early as age 9. Catch-up vaccination is recommended for males up to age 21 and females up to age 26 who have not been previously vaccinated. In certain cases, vaccination is also recommended for some adults aged 27 through 45 years, based on individual risk factors and healthcare provider recommendations.